General Information

  • ID:  hor006292
  • Uniprot ID:  Q76KW6
  • Protein name:  C-type natriuretic peptide
  • Gene name:  cnp
  • Organism:  Acipenser transmontanus (White sturgeon)
  • Family:  Natriuretic peptide family
  • Source:  Animal
  • Expression:  Expressed in brain, but not in atrium or ventricle.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Acipenser (genus), Acipenserini (tribe), Acipenserinae (subfamily), Acipenseridae (family), Acipenseroidei (suborder), Acipenseriformes (order), Chondrostei (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0006182 cGMP biosynthetic process; GO:0007168 receptor guanylyl cyclase signaling pathway; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  MQQGRGCFGMKLDRIGSMSGLGC
  • Length:  23(128-150)
  • Propeptide:  MSISSSSSSSSSSSSCLLLISLMLLAASCQGRPDLQHRNHKSQLAGLFGAEVAALLEDAGAADGSSGEEAALSQRAPPSIRALHPRSGRLGLRDDLEAEPPAENKPRRRLLKDFMSSRKMFRGRTKKMQQGRGCFGMKLDRIGSMSGLGC
  • Signal peptide:  MSISSSSSSSSSSSSCLLLISLMLLAASCQG
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic (By similarity).
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  45861
  • Structure ID:  AF-Q76KW6-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006292_AF2.pdbhor006292_ESM.pdb

Physical Information

Mass: 282550 Formula: C98H166N32O30S5
Absent amino acids: AEHNPTVWY Common amino acids: G
pI: 8.83 Basic residues: 3
Polar residues: 10 Hydrophobic residues: 4
Hydrophobicity: -7.83 Boman Index: -2900
Half-Life / Aliphatic Index: 30 hour Aliphatic Index: 50.87
Instability Index: 2310.43 Extinction Coefficient cystines: 125
Absorbance 280nm: 5.68

Literature

  • PubMed ID:  15072558
  • Title:  Four natriuretic peptides (ANP, BNP, VNP and CNP) coexist in the sturgeon: identification of BNP in fish lineage.